abstract：:Inflammation is a vital defense mechanism of living organisms. However, persistent and chronic inflammation may lead to severe pathological processes and evolve into various chronic inflammatory diseases (CID), e.g. rheumatoid arthritis, multiple sclerosis, multiple sclerosis, systemic lupus erythematosus or inflammat...

journal_title：Physiological research

authors： Koziolová E,Venclíková K,Etrych T

更新日期：2018-10-30 00:00:00

abstract：:Considerable evidence demonstrates that phenotypic switching of vascular smooth muscle cells (VSMCs) is influenced by aging and hypertension. During phenotypic switching, VSMCs undergo a switch to a proliferative and migratory phenotype, with this switch being a common pathology in cardiovascular diseases. The aim of ...

journal_title：Physiological research

authors： Zhang L,Xu Z,Wu Y,Liao J,Zeng F,Shi L

更新日期：2018-08-16 00:00:00

abstract：:Ultraviolet-radiation exerts a well-known role in the development of various ocular diseases and may contribute to the progress of age-related macular degeneration. Therefore, the use of compounds able to protect the eyes from UV-induced cellular damage is challenging. The aim of this study has been to test the protec...

journal_title：Physiological research

authors： Vizzarri F,Palazzo M,Bartollino S,Casamassima D,Parolini B,Troiano P,Caruso C,Costagliola C

更新日期：2018-07-17 00:00:00

abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...

journal_title：Physiological research

authors： Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek M

更新日期：2018-07-17 00:00:00

abstract：:Endothelin-1 (ET-1) acts on ET(A) and ET(B) receptors and has been implicated in hemorrhagic shock (shock). We determined effect of shock and resuscitation by hypertonic saline (saline) or centhaquin on ET(A) and ET(B) receptor expression. Rats were anesthetized, a pressure catheter was placed in the left femoral arte...

journal_title：Physiological research

authors： Briyal S,Gandhakwala R,Khan M,Lavhale MS,Gulati A

更新日期：2018-06-27 00:00:00

abstract：:The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and ...

journal_title：Physiological research

authors： Li W,Abdul Y,Ward R,Ergul A

更新日期：2018-06-27 00:00:00

abstract：:Impressive advances in molecular genetic techniques allow to analyze the effects of natural selection on the development of human genome. For example, the trend towards blonde hair and blue eyes was documented. The approach to analyze possible effects of natural selection on the evolution of recent phenotypes with hig...

journal_title：Physiological research

authors： Poledne R,Zicha J

更新日期：2018-05-04 00:00:00

abstract：:Research and clinical implications on novel cardiac biomarkers has intensified significantly in the past few years. The high-sensitive troponin T (hscTnT) assay plays a dominant role in diagnostic algorithm regarding myocardial injury in adults. Despite generally accepted use of hscTnT there are no data about physiolo...

journal_title：Physiological research

authors： Jehlicka P,Huml M,Rajdl D,Mockova A,Matas M,Dort J,Masopustova A

更新日期：2018-05-04 00:00:00

abstract：:The expression of aquaporins (AQPs) in the fetal porcine urinary tract and its relation to gestational age has not been established. Tissue samples from the renal pelvis, ureter, bladder and urethra were obtained from porcine fetuses. Samples were examined by RT-PCR (AQPs 1-11), QPCR (AQPs positive on RT-PCR), and imm...

journal_title：Physiological research

authors： Jakobsen LK,Trelborg KF,Kingo PS,Hoyer S,Andersson KE,Djurhuus JC,Norregaard R,Olsen LH

更新日期：2018-05-04 00:00:00

abstract：:Because greater Akt substrate of 160 kDa (AS160) phosphorylation has been reported in insulin-stimulated skeletal muscles without improved Akt activation several hours post-exercise, we hypothesized that prior exercise would result in attenuated AS160 dephosphorylation in insulin-stimulated rat skeletal muscle. Epitro...

journal_title：Physiological research

authors： Arias EB,Wang H,Cartee GD

更新日期：2018-03-16 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) has proven efficacious in reducing or even eliminating cardiac dyssynchrony and thus improving heart failure symptoms. However, quantification of mechanical dyssynchrony is still difficult and identification of CRT candidates is currently based just on the morphology and width o...

journal_title：Physiological research

authors： Kittnar O,Riedlbauchová L,Tomis J,LoŽek M,Valeriánová A,Hrachovina M,Mlček M,Huptych M,Janoušek J,Lhotská L

更新日期：2017-12-30 00:00:00

abstract：:Activation of calmodulin dependent protein kinase (CaMK)II by exercise is beneficial in controlling membrane lipids associated with type 2 diabetes and obesity. Regulation of lipid metabolism is crucial in the improvement of type 2 diabetes and obesity associated symptoms. The role of CaMKII in membrane associated lip...

journal_title：Physiological research

authors： Joseph JS,Ayeleso AO,Mukwevho E

更新日期：2017-12-20 00:00:00

abstract：:Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance o...

journal_title：Physiological research

authors： Xie X,Guo A,Wu T,Hu Q,Huang L,Yao C,Zhao B,Zhang W,Chi B,Lu P,Zhao Z,Fu Z

更新日期：2017-11-24 00:00:00

abstract：:Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB do...

journal_title：Physiological research

authors： Šeda O,Šedová L,Včelák J,Vaňková M,Liška F,Bendlová B

更新日期：2017-09-26 00:00:00

abstract：:T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as end...

journal_title：Physiological research

authors： Kolesarova A,Maruniakova N,Kadasi A,Halenar M,Marak M,Sirotkin AV

更新日期：2017-09-22 00:00:00

abstract：:At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as w...

journal_title：Physiological research

authors： Haskova K,Javorka M,Czippelova B,Zibolen M,Javorka K

更新日期：2017-09-22 00:00:00

abstract：:Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympath...

journal_title：Physiological research

authors： Zila I,Mokra D,Kopincova J,Kolomaznik M,Javorka M,Calkovska A

更新日期：2017-09-22 00:00:00

abstract：:Numerous countermeasures have been proposed to minimize microgravity-induced physical deconditioning, but their benefits are limited. The present study aimed to investigate whether personalized aerobic exercise based on artificial gravity (AG) mitigates multisystem physical deconditioning. Fourteen men were assigned t...

journal_title：Physiological research

authors： Li XT,Yang CB,Zhu YS,Sun J,Shi F,Wang YC,Gao Y,Zhao JD,Sun XQ

更新日期：2017-09-22 00:00:00

abstract：:This study attempted to compare the muscle fiber morphological responses to dynamic electrical muscle stimulation (DEMS) and dynamic hydraulic stimulation (DHS) in rats under hindlimb suspension (HLS). DEMS at 1 Hz, 50 Hz and 100 Hz for 10 min/day, 5 days/week were introduced to the animals' right quadriceps. Static a...

journal_title：Physiological research

authors： Hu M,Lam H,Yeh R,Teeratananon M,Qin YX

更新日期：2017-07-18 00:00:00

abstract：:Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their level...

journal_title：Physiological research

authors： Cibičková Ľ,Langová K,Vaverková H,Kubíčková V,Karásek D

更新日期：2017-07-18 00:00:00

abstract：:Gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS) are distinct pathologies with impaired insulin sensitivity as a common feature. The aim of this study was to evaluate the response of fat tissue adipokines and gastrointestinal incretins to glucose load in patients diagnosed with one of the two d...

journal_title：Physiological research

authors： Vejrazkova D,Lischkova O,Vankova M,Stanicka S,Vrbikova J,Lukasova P,Vcelak J,Vacinova G,Bendlova B

更新日期：2017-05-04 00:00:00

abstract：:Ferritin and increased iron stores first appeared on the list of cardiovascular risk factors more than 30 years ago and their causal role in the pathogenesis of atherosclerosis has been heavily discussed since the early 1990s. It seems that besides traditional factors such as hyperlipoproteinemia, hypertension, diabet...

journal_title：Physiological research

authors： Kraml P

更新日期：2017-04-05 00:00:00

abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...

journal_title：Physiological research

authors： Ziaaldini MM,Hosseini SR,Fathi M

更新日期：2017-03-31 00:00:00

abstract：:Familial hypercholesterolemia (FH) is most frequently caused by LDLR or APOB mutations. Therefore, the aim of our study was to examine the genetic background of Slovak patients suspected of FH. Patients with clinical suspicion of FH (235 unrelated probands and 124 family relatives) were recruited throughout Slovakia d...

journal_title：Physiological research

authors： Gabčová D,Vohnout B,Staníková D,Hučková M,Kadurová M,Debreová M,Kozárová M,Fábryová Ľ,Staník J,Klimeš I,Rašlová K,Gašperiková D

更新日期：2017-03-31 00:00:00

abstract：:Pathophysiological mechanisms underlying the development of renal dysfunction and progression of congestive heart failure (CHF) remain poorly understood. Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway ...

journal_title：Physiological research

authors： Sporková A,Husková Z,Škaroupková P,Rami Reddy N,Falck JR,Sadowski J,Červenka L

更新日期：2017-03-31 00:00:00

abstract：:Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. The present study was aimed to examine cognitive changes after prenatal and neonatal MA treatment in combination with chronic MA exposure in adulthood of male rats...

journal_title：Physiological research

authors： Hrebíčková I,Ševčíková M,Nohejlová K,Šlamberová R

更新日期：2016-12-22 00:00:00

abstract：:MiRNAs are important regulators of gene expression and changes in their levels are linked with various pathological states, including solid tumors. MiR-215 has been identified as a tumor suppressor in colorectal cancer (CRC). Following our previous in vitro and in vivo experiments, the aim of this project was to study...

journal_title：Physiological research

authors： Merhautová J,Vychytilová-Faltejsková P,Demlová R,Slabý O

更新日期：2016-12-21 00:00:00

abstract：:Metabolic acidosis could occur due to either endogenous acids accumulation or bicarbonate loss from the gastrointestinal tract or commonly from the kidney. This study aimed to investigate the possible underlying mechanism(s) of chronic acidosis-induced cardiac contractile and electrical changes in rats. Twenty four ad...

journal_title：Physiological research

authors： Lasheen NN,Mohamed GF

更新日期：2016-12-13 00:00:00

abstract：:Hemodynamics in the distal end-to-side anastomosis is related to early development of intimal hyperplasia and bypass failure. In this study we investigated the effect of diameter ratios between the target artery and the bypass at three different angles of the connection. The pulsatile flow field was visualized using p...

journal_title：Physiological research

authors： Grus T,Lambert L,Matěcha J,Grusová G,Špaček M,Mlček M

更新日期：2016-12-13 00:00:00

abstract：:Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury due to prevention of necroptotic cell death. Its inactive analogue necrostatin-1i (Nec-1i), lacking RIP1 activity, serves as a suitable control. It is unknown if these agents influence the hea...

journal_title：Physiological research

authors： Szobi A,Rajtik T,Adameova A

更新日期：2016-11-23 00:00:00

abstract：:This study was designated to estimate protective role of ETA and ETB receptor antagonist against endothelin 1 (ET-1)-induced oxidative stress in lungs and determine whether these effects are mediated by nitric oxide (NO) synthase. Experiments were performed on Wistar rats divided into the following groups: I - saline ...

journal_title：Physiological research

authors： Kleniewska P,Gorąca A

更新日期：2016-11-23 00:00:00

abstract：:The goal of this study was to identify small molecular weight compounds that bind to sclerostin using in-silico methods because of the established importance of sclerostin-based therapies for the treatment of disease characterized by low bone mass. The zinc database (Zdb) revealed that nine potential molecules bind to...

journal_title：Physiological research

authors： Muthusamy K,Mohan S,Nagamani S,Kesavan C

更新日期：2016-11-23 00:00:00

abstract：:TGF-beta superfamily members including bone morphogenetic proteins (BMPs) and their receptors (BMPR-1A, -1B and -2) have been shown to be important for reproductive function in both males and females, while information on the role of BMPs in males is limited. Functional studies on select BMPs and BMP receptors have de...

journal_title：Physiological research

authors： Ciller IM,Palanisamy SK,Ciller UA,McFarlane JR

更新日期：2016-11-08 00:00:00

abstract：:Aquaporin proteins (AQPs) are a family of channels expressed in numerous mammalian tissues, where they play a fundamental role in regulating water transport across cell membranes. Based on reports that AQPs are present in the reproductive system and participate in reproductive processes, our aim was to investigate the...

journal_title：Physiological research

authors： Skowronska A,Mlotkowska P,Majewski M,Nielsen S,Skowronski MT

更新日期：2016-11-08 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors. PPARgamma acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin res...

journal_title：Physiological research

authors： Kvandová M,Majzúnová M,Dovinová I

更新日期：2016-10-24 00:00:00

abstract：:Maghemite (gamma-Fe2O3) nanoparticles, 12 nm in size, were prepared by co-precipitation of Fe(II) and Fe(III) chlorides with ammonium hydroxide and oxidation with hydrogen peroxide. To achieve stability and biocompatibility, obtained particles were coated with silica, to which glucose and ascorbic acid were bound by d...

journal_title：Physiological research

authors： Moskvin M,Horák D

更新日期：2016-10-20 00:00:00

abstract：:Remote ischemic preconditioning (RIPC) is a novel strategy of protection against ischemia-reperfusion (IR) injury in the heart (and/or other organs) by brief episodes of non-lethal IR in a distant organ/tissue. Importantly, RIPC can be induced noninvasively by limitation of blood flow in the extremity implying the app...

journal_title：Physiological research

authors： Ravingerova T,Farkasova V,Griecsova L,Carnicka S,Murarikova M,Barlaka E,Kolar F,Bartekova M,Lonek L,Slezak J,Lazou A

更新日期：2016-09-19 00:00:00

abstract：:The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...

journal_title：Physiological research

authors： Barančík M,Grešová L,Barteková M,Dovinová I

更新日期：2016-09-19 00:00:00

abstract：:Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese wome...

journal_title：Physiological research

authors： Kloučková J,Lacinová Z,Kaválková P,Trachta P,Kasalický M,Haluzíková D,Mráz M,Haluzík M

更新日期：2016-07-18 00:00:00

abstract：:The circadian rhythms of many behavioral and physiological functions are regulated by the major circadian pacemaker in the suprachiasmatic nucleus. Long-term opiate addiction and drug withdrawal may affect circadian rhythmicity of various hormones or the sleep/activity pattern of many experimental subjects; however, l...

journal_title：Physiological research

authors： Pačesová D,Novotný J,Bendová Z

更新日期：2016-07-18 00:00:00